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. 1973 Nov;135(3):411-6.
doi: 10.1042/bj1350411.

Palmitoyl-coenzyme A synthetase. Isolation of an enzyme-bound intermediate

Palmitoyl-coenzyme A synthetase. Isolation of an enzyme-bound intermediate

J Bar-Tana et al. Biochem J. 1973 Nov.

Abstract

An enzyme-bound intermediate of the overall reaction catalysed by rat liver microsomal long-chain fatty acyl-CoA synthetase is described. It was found to contain equimolar amounts of adenylate and fatty acid moieties bound to protein, and was stabilized by ATP. The intermediate reacted with CoA to give palmitoyl-CoA.

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