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Clinical Trial
. 1973 Dec;36(6):936-41.
doi: 10.1136/jnnp.36.6.936.

Anticholinergic withdrawal and benzhexol treatment in Parkinson's disease

P M Horrocks, D J Vicary, J E Rees, J D Parkes, C D Marsden
Clinical Trial

Anticholinergic withdrawal and benzhexol treatment in Parkinson's disease

P M Horrocks et al. J Neurol Neurosurg Psychiatry. 1973 Dec.

Abstract

The effects of slow withdrawal of anticholinergic medication and addition of benzhexol (8 mg/day) have been studied in patients with Parkinson's disease on stable levodopa therapy. Withdrawal of anticholinergic drugs led to measurable and often severe deterioration in about two-thirds of patients. Addition of benzhexol produced a slight but definite additional improvement in those patients in whom anticholinergics were withdrawn before the trial. Anticholinergic drugs thus still have a part to play in the treatment of Parkinson's disease, for they produce benefit in addition to that provided by levodopa.

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References

    1. Science. 1969 Nov 14;166(3907):899-901 - PubMed
    1. Br Med J. 1971 May 29;2(5760):487-91 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1973 Feb;36(1):10-4 - PubMed

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