[Effect of nonachlazine on cerebral circulation]

Abstract

It has been shown in acute experiments on anesthetized cats that nonachlazine in a dose of 2.5 mg/kg produces a short-term decrease followed by more prolonged elevation of the tone of cerebral vessels, lower extremities and systemic arterial blood pressure. Previous blocking of alpha- and beta-adrenoreceptors decreases or abolishes the development of the above effects. In a dose of 5 mg/kg nonachlazine produces no rise in the tone of intracranial vessels, but increases local and common cerebral blood flow. An increase in PO2 in the brain cortex correlates well with a rise in the blood flow.