[Guinea pig nipple as a model for the investigation of melasma (author's transl)]
[Article in
French]
- PMID: 478059
Item in Clipboard
[Guinea pig nipple as a model for the investigation of melasma (author's transl)]
[Article in
French]
Dermatologica.
1979.
Abstract
The nipples of male tan guinea pigs were used to test the effects on the skin of oral contraceptive pills and drugs. The daily topically applied doses were 1/2,000 of a pill. After 3 weeks, the nipples treated with solutions of ethinyloestradiol-containing pills had grown (200-300%), the epidermis showed acanthosis (150-250%) and strong hyperpigmentation. Mestranol-containing pills as well as pure progestogen substances did not produce these effects.
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