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. 1979;159(3):210-6.

[Guinea pig nipple as a model for the investigation of melasma (author's transl)]

[Article in French]
R Brun, P Laugier
  • PMID: 478059

[Guinea pig nipple as a model for the investigation of melasma (author's transl)]

[Article in French]
R Brun et al. Dermatologica. 1979.

Abstract

The nipples of male tan guinea pigs were used to test the effects on the skin of oral contraceptive pills and drugs. The daily topically applied doses were 1/2,000 of a pill. After 3 weeks, the nipples treated with solutions of ethinyloestradiol-containing pills had grown (200-300%), the epidermis showed acanthosis (150-250%) and strong hyperpigmentation. Mestranol-containing pills as well as pure progestogen substances did not produce these effects.

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