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. 1979 Jul;25(1):366-75.
doi: 10.1128/iai.25.1.366-375.1979.

Efficacy of antimicrobial therapy in experimental rat pneumonia: effects of impaired phagocytosis

I A Bakker-Woudenberg, J Y de Jong-Hoenderop, M F Michel

Efficacy of antimicrobial therapy in experimental rat pneumonia: effects of impaired phagocytosis

I A Bakker-Woudenberg et al. Infect Immun. 1979 Jul.

Abstract

The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy was studied in normal rats and in rats treated with cobra venom factor. This factor was used to selectively suppress the phagocytosis of pneumococci as a result of complement depletion. Although complete recovery from the infection occurred in normal rats after appropriate penicillin therapy, this was not the case in cobra venom factor-treated rats. Within the limitations of this study, evidence is presented for loss of antibiotic activity as a consequence of impaired phagocytosis.

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