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. 1979 Jul;25(1):440-5.
doi: 10.1128/iai.25.1.440-445.1979.

Immunization of mice against coccidioidomycosis with a subcellular vaccine

D Pappagianis, R Hector, H B Levine, M S Collins

Immunization of mice against coccidioidomycosis with a subcellular vaccine

D Pappagianis et al. Infect Immun. 1979 Jul.

Abstract

In vitro-cultivated spherules of Coccidioides immitis were disrupted in a Braun homogenizer. The resultant wall fragments were separated from cell sap and endospores by centrifugation. Extraction of the walls with phosphate-buffered saline yielded a subcellular fraction that was immunogenic in mice. This fraction, which contained polysaccharide and protein, gave substantial protection against intranasal challenge with a usually lethal dose (1,000) of arthrospores, provided that it was administered with adjuvant.

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