doi: 10.1002/ijc.2910240109.
Enhancement of carcinoembryonic antigen expression by interferon
- PMID: 478691
- DOI: 10.1002/ijc.2910240109
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Enhancement of carcinoembryonic antigen expression by interferon
Int J Cancer.
.
Abstract
Human interferon decreased DNA but not RNA synthesis in a human colon carcinoma cell line, WiDr; in addition, there was a two- to three-fold increase in the expression of a tumor-associated antigen, carcinoembryonic antigen. In contrast, interferon had no effect on a normal human diploid cell line, WI-38. Thus, in addition to its anti-cellular effect against tumor cells, interferon can also modulate tumor antigenicity.
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