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. 1972 Sep;2(3):122-31.
doi: 10.1128/AAC.2.3.122.

Cephamycins, a new family of beta-lactam antibiotics. I. Production by actinomycetes, including Streptomyces lactamdurans sp. n

E O Stapley, M Jackson, S Hernandez, S B Zimmerman, S A Currie, S Mochales, J M Mata, H B Woodruff, D Hendlin

Cephamycins, a new family of beta-lactam antibiotics. I. Production by actinomycetes, including Streptomyces lactamdurans sp. n

E O Stapley et al. Antimicrob Agents Chemother. 1972 Sep.

Abstract

A number of actinomycetes isolated from soil were found to produce one or more members of a new family of antibiotics, the cephamycins, which are structurally related to cephalosporin C. The cephamycins were produced in submerged fermentation in a wide variety of media by one or more of eight different species of Streptomyces, including a newly described species, S. lactamdurans. These antibiotics exhibit antibacterial activity against a broad spectrum of bacteria which includes many that are resistant to the cephalosporins and penicillins.

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References

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