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. 1973 Oct;4(4):410-4.
doi: 10.1128/AAC.4.4.410.

Biosynthesis of monensin

L E Day, J W Chamberlin, E Z Gordee, S Chen, M Gorman, R L Hamill, T Ness, R E Weeks, R Stroshane

Biosynthesis of monensin

L E Day et al. Antimicrob Agents Chemother. 1973 Oct.

Abstract

The biosynthesis of monensin by Streptomyces cinnamonensis was studied by using (14)C-labeled glucose, acetate, propionate, butyrate, and methionine. The results indicated that the antibiotic is synthesized from five acetate, seven propionate, and one butyrate molecules. The o-methyl group of monensin is derived from methionine, whereas the terminal hydroxymethyl group is incorporated from acetate.

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References

    1. Antimicrob Agents Chemother (Bethesda). 1967;7:349-52 - PubMed
    1. Antimicrob Agents Chemother (Bethesda). 1967;7:353-8 - PubMed
    1. Antimicrob Agents Chemother (Bethesda). 1967;7:359-62 - PubMed
    1. J Antibiot (Tokyo). 1969 Nov;22(11):545-50 - PubMed
    1. J Am Chem Soc. 1967 Oct 25;89(22):5737-9 - PubMed

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