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. 1973 Oct;49(2):253-7.
doi: 10.1111/j.1476-5381.1973.tb08370.x.

Decreased synthesis of DNA in regenerating rat liver after the administration of reserpine

A Cihák, K Vaptzarova

Decreased synthesis of DNA in regenerating rat liver after the administration of reserpine

A Cihák et al. Br J Pharmacol. 1973 Oct.

Abstract

1. Reserpine given to rats before the enhanced synthesis of DNA begins 14h after partial hepatectomy markedly depresses thymidine uptake into DNA at 24 hours.2. At this time decreased activity of liver thymidine kinase but unchanged thymidine 5'-nucleotidase were observed.3. Reserpine has no effect on DNA synthesis when administered simultaneously with the labelled thymidine 2 h before killing.4. With depressed DNA synthesis after reserpine administration there is no significant decrease of liver RNA synthesis.

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References

    1. J Physiol. 1958 Apr 3;141(1):132-55 - PubMed
    1. Experientia. 1969 Dec 15;25(12):1240-2 - PubMed
    1. J Pharmacol Exp Ther. 1962 Nov;138:208-17 - PubMed
    1. J Pharmacol Exp Ther. 1961 Feb;131:171-8 - PubMed
    1. Experientia. 1972 Dec 15;28(12):1418 - PubMed