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. 1973 Oct;49(2):316-21.
doi: 10.1111/j.1476-5381.1973.tb08378.x.

Possible modulating influence of frontal cortex on nigro-striatal function

S D Glick, S Greenstein

Possible modulating influence of frontal cortex on nigro-striatal function

S D Glick et al. Br J Pharmacol. 1973 Oct.

Abstract

1. After administration of (+)-amphetamine, rats with unilateral ablations of the frontal cortex rotated either ipsilaterally or contralaterally as a function of time after surgery.2. At early postoperative intervals (1-7 days), rotation was towards the side of the lesion.3. At later times (15-30 days), rotation was towards the intact side.4. Repeated testing with amphetamine appeared to slow the time-course of changes in rotational behaviour.5. These results suggest that a dopaminergic nigro-striatal system is modulated by the frontal cortex and that unilateral removal of the latter produces a denervation supersensitivity of the former.

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References

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    1. Acta Physiol Scand Suppl. 1971;367:1-48 - PubMed
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