Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979;45(3):185-93.
doi: 10.1007/BF01244407.

Opposite effects of naloxone on substance P-induced changes in brain DOPA synthesis and in locomotor activity in rats

J A Garcia-Sevilla, T Magnusson, A Carlsson

Opposite effects of naloxone on substance P-induced changes in brain DOPA synthesis and in locomotor activity in rats

J A Garcia-Sevilla et al. J Neural Transm. 1979.

Abstract

Intracerebroventricular injection of substance P (SP) enhanced the synthesis of dopamine and noradrenaline (measured as increase in DOPA formation after inhibition of the aromatic L-amino-acid decarboxylase) in rat brain. These biochemical effects were blocked in most brain regions by pretreatment with naloxone. SP also induced vasodilation, salivation and increased locomotor activity. These effects were not antagonized, but, in the case of locomotor activity, potentiated by naloxone. The data suggest the existence of specific SP-containing neuronal pathways for behavior, which pathways are not related to those regulating the synthesis of brain catecholamines.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Brain Res. 1978 Jun 23;149(1):97-105 - PubMed
    1. J Neural Transm. 1976;38(2):89-93 - PubMed
    1. Brain Res. 1978 Aug 11;151(3):469-78 - PubMed
    1. Science. 1975 Nov 28;190(4217):889-90 - PubMed
    1. Brain Res. 1978 Aug 4;151(2):392-8 - PubMed

LinkOut - more resources