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Comparative Study
. 1973 Dec;4(6):783-94.
doi: 10.1016/0090-6980(73)90114-7.

A congenital defect in platelet prostaglandin production associated with impaired hemostasis in storage pool disease

A L Willis, H J Weiss
Comparative Study

A congenital defect in platelet prostaglandin production associated with impaired hemostasis in storage pool disease

A L Willis et al. Prostaglandins. 1973 Dec.

Abstract

PIP: Prostaglandin (PG) production was found to be impaired in platelets from patients with 'storage pool disease', a well characterized hemostatic disorder. This finding adds to the growing body of evidence which implicates prostaglandin synthesis or a similar arachidonate-consuming process in second phase aggregation and the accompanying platelet release reaction. Prostaglandin production is not impaired in platelets from patients with thrombasthenia. It is thus unlikely that aggregation 'per se' is a stimulus for PG production, because thrombasthenic platelets are virtually incapable of aggregation.

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