Observations on the effect of injection of lymphocytes from multiple sclerosis and Guillain-Barré syndrome in the rabbit eye model

Abstract

The effect of 10 X 10(5) peripheral blood lymphocytes (PBL) obtained from patients with multiple sclerosis (MS), Guillain-Barré syndrome (GBS) and healthy controls was studied after injection into the rabbit eye. Infiltration of inflammatory cells, strikingly localized to myelinated strips, was obtained with PBL from some of the MS patients and controls, indicating the non-specificity of the phenomenon. PBL from 2 GBS patients gave the strongest infiltration. No effect was obtained with 10 X 10(4) PBL or CSF lymphocytes from MS patients, indicating that the number of lymphocytes is an essential factor in the induction of lesions.