Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1974 Jan 5;1(5896):5-10.
doi: 10.1136/bmj.1.5896.5.

Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines

W H Inman, W W Mushin

Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines

W H Inman et al. Br Med J. .

Abstract

Analysis of data derived from 130 reports of jaundice occurring after anaesthesia with halothane showed a significant relation between the number of exposures to this anaesthetic and the rapidity with which jaundice develops after exposure. This is considered to provide strong evidence of a cause-effect relationship between the use of halothane and jaundice. Out of 114 patients with complete anaesthetic histories 94 (82%) had been exposed more than once; of those so exposed 80% had been anaesthetized with halothane more than once within 28 days. Altogether 66 (51%) of the 130 patients died.

PubMed Disclaimer

References

    1. Br Med J. 1964 Aug 8;2(5405):329-41 - PubMed
    1. Can Anaesth Soc J. 1963 Nov;10:531-8 - PubMed
    1. Br Med J. 1971 Feb 20;1(5746):448-50 - PubMed
    1. N Engl J Med. 1968 Oct 10;279(15):798-801 - PubMed
    1. Br Med J. 1968 Apr 27;2(5599):193-9 - PubMed

LinkOut - more resources