doi: 10.1126/science.183.4122.325.
An enzymatic mechanism for the antithrombotic and antihemostatic actions of aspirin
- PMID: 4809076
- DOI: 10.1126/science.183.4122.325
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An enzymatic mechanism for the antithrombotic and antihemostatic actions of aspirin
Science.
.
Abstract
Aspirin-type drugs may inhibit irreversible clumping of human blood platelets by blocking the enzymatic conversion of arachidonic acid to a hitherto undiscovered factor, labile aggregation-stimulating substance, which triggers aggregation and to prostaglandin E(2), which sensitizes the platelets to its aggregatory effects.
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