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. 1974 Feb;36(2):221-5.
doi: 10.1152/jappl.1974.36.2.221.

Inhibition of transport of 47Ca and 85Sr by lanthanum in canine cortical bone

G R Paradis, J B Bassingthwaighte, P J Kelly

Inhibition of transport of 47Ca and 85Sr by lanthanum in canine cortical bone

G R Paradis et al. J Appl Physiol. 1974 Feb.

Abstract

Deposition of 85Sr and 47Ca and blood flow (measured by iodoantipyrine washout) were determined in the tibial cortex of adult dogs after injection of graded doses of lanthanum chloride (LaCl3) and potassium cyanide (KCN) into the right tibial nutrient artery. Deposition of 85Sr and 47Ca, expressed in milliliters per gram of cortical bone in 10 min, was decreased after injections of lanthanum, 0.045 ± 0.008 (mean ± SE) compared to 0.097 ± 0.01 in control experiments (P < 0.005). Blood flow was unchanged. Injection of KCN did not affect the mean value of uptake of mineral (0.108 ± 0.01 vs. 0.097 ± 0.01) over the whole range of KCN dosage. Blood flow tended to be slightly higher with lower doses of KCN. These data support the concept of a transport system in bone for bone-seeking isotopes such as 85Sr and 47Ca.

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Figures

FIG. 1
FIG. 1
Disappearance curve for 85Sr from arterial blood sampled at 1-min intervals.
FIG. 2
FIG. 2
Effect of La3+ on blood flow (upper) and mineral deposition (lower). Test side was right tibia; control side was left.
FIG. 3
FIG. 3
Effect of KCN on blood flow (upper) and mineral deposition (lower). Correlation coefficient, r, for log deposition ratio versus dose is −0.53 (P < 0.005). For log flow ratio versus dose, r = −0.62 (P < 0.001).
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