doi: 10.1126/science.183.4129.1085.
Arachidonic acid causes sudden death in rabbits
- PMID: 4812036
- DOI: 10.1126/science.183.4129.1085
Item in Clipboard
Arachidonic acid causes sudden death in rabbits
Science.
.
Abstract
Injection of sodium arachidonate (1.4 milligrams per kilogram) into the marginal ear veins of rabbits caused death within 3 minutes. Histological examination showed platelet thrombi in the microvasculature of the lungs. Rabbits were protected from the lethal effects of arachidonic acid by pretreatment with aspirin. Fatty acids closely related to arachidonic acid did not cause death.
Similar articles
-
Letter: Arachidonic acid and platelet aggregation.Lancet. 1974 Nov 2;2(7888):1080. doi: 10.1016/s0140-6736(74)92180-1. Lancet. 1974. PMID: 4138267 No abstract available.
-
Arachidonic acid induced mortality in animals - an appropriate model for the evaluation of antithrombotic drugs?Agents Actions Suppl. 1979;(4):175-83. Agents Actions Suppl. 1979. PMID: 291305
-
Mechanism of the protective action of Bay-u-3405, a new specific thromboxane receptor antagonist, in arachidonate-induced sudden death.Methods Find Exp Clin Pharmacol. 1991 Mar;13(2):105-10. Methods Find Exp Clin Pharmacol. 1991. PMID: 1906568
-
Pharmacology of platelet-affecting drugs.Circulation. 1980 Dec;62(6 Pt 2):V26-41. Circulation. 1980. PMID: 6254690 Review. No abstract available.
-
Unstable metabolites of arachidonic acid and their role in haemostasis and thrombosis.Br Med Bull. 1978 May;34(2):129-35. doi: 10.1093/oxfordjournals.bmb.a071482. Br Med Bull. 1978. PMID: 350335 Review. No abstract available.
Cited by
-
Phorbol myristate acetate: in vivo effects upon neutrophils, platelets, and lung.Am J Pathol. 1980 Oct;101(1):79-92. Am J Pathol. 1980. PMID: 7446704 Free PMC article.
-
Vasoconstrictor response to arachidonic acid in the isolated hind limb of the dog.Br J Pharmacol. 1977 Feb;59(2):269-73. doi: 10.1111/j.1476-5381.1977.tb07489.x. Br J Pharmacol. 1977. PMID: 837014 Free PMC article.
-
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.Proc Natl Acad Sci U S A. 1974 Sep;71(9):3400-4. doi: 10.1073/pnas.71.9.3400. Proc Natl Acad Sci U S A. 1974. PMID: 4215079 Free PMC article.
-
Dietary carbohydrate influences tissue fatty acid and lipid composition in the copper-deficient rat.Biol Trace Elem Res. 1989-1990 Winter;23:77-87. doi: 10.1007/BF02917179. Biol Trace Elem Res. 1989. PMID: 2484428
-
Gram-positive bacteria-induced granulocytopenia and pulmonary leukostasis in rabbits.Infect Immun. 1982 Jul;37(1):336-43. doi: 10.1128/iai.37.1.336-343.1982. Infect Immun. 1982. PMID: 6286493 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
