doi: 10.1007/BF00498459.
Effect of age on levels of diazepam in plasma and brain of rats
- PMID: 481615
- DOI: 10.1007/BF00498459
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Effect of age on levels of diazepam in plasma and brain of rats
Naunyn Schmiedebergs Arch Pharmacol.
1979 Jun.
Abstract
The pharmacokinetics and distribution in brain and cerebellum of diazepam after a single dose were studied in middle aged (6 months) and old (18 months) rats. Following the single intravenous bolus of 5 mg/kg diazepam was eliminated more slowly in old rats (T 1/2 (beta) = 3.1 H) than in middle aged rats (1.4H). This was due to an increase in the apparent volume of distribution Vd beta from 11.0 l/kg (control rats) to 29.5 l/kg. Concentrations of diazepam in brain and cerebellum were in the same range (0.5-1.1 ng/mg) in both groups after this dose. We conclude that the distribution of diazepam is age-dependent which might be due to an altered body composition.
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