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. 1979 Aug;4(4):425-35.
doi: 10.1007/BF00964637.

Regulatory interrelations between GABA and polyamines. I. Brain GABA levels and polyamine metabolism

N Seiler, G Bink, J Grove

Regulatory interrelations between GABA and polyamines. I. Brain GABA levels and polyamine metabolism

N Seiler et al. Neurochem Res. 1979 Aug.

Abstract

Elevation of brain GABA levels by GABA-T inhibition is accompanied by a decrease of S-adenosylmethionine decarboxylase activity. This is followed by an increase of ornithine decarboxylase activity and a severalfold increase of brain putrescine levels. Spermidine and spermine levels are not significantly affected under these conditions. These unexpected findings support a regulatory interaction between GABA and polyamine metabolism.

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