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Comparative Study
. 1974 Jan;76(1):93-7.
doi: 10.1093/genetics/76.1.93.

Alpha-hydroxyacid oxidase genetics in the mouse: evidence for two genetic loci and a tetrameric subunit structure for the liver isozyme

J Duley, R S Holmes
Comparative Study

Alpha-hydroxyacid oxidase genetics in the mouse: evidence for two genetic loci and a tetrameric subunit structure for the liver isozyme

J Duley et al. Genetics. 1974 Jan.

Abstract

We have examined a polymorphism for liver GOX in inbred strains of the mouse Mus musculus. Genetic studies demonstrated that the two phenotypes for this enzyme present in BALB/C and NZC parental strains segregated as though they were controlled by codominant alleles at a single autosomal locus (GOX) which mapped closely to the agouti locus in linkage group V. Kidney HAOX activity is invariant in these inbred strains and is encoded by a separate genetic locus designated HAOX. BALB/C x NZC F(1) hybrid mice exhibited three intermediate forms of liver GOX activity, in addition to the parental enzymes, which is consistent with a tetrameric subunit structure.

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References

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