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. 1974 Apr 26;184(4135):477-80.
doi: 10.1126/science.184.4135.477.

Mycoplasma contamination of cultured amniotic fluid cells: potential hazard to prenatal chromosomal diagnosis

E L Schneider, E J Stanbridge, C J Epstein, M Golbus, G Abbo-Halbasch, G Rodgers

Mycoplasma contamination of cultured amniotic fluid cells: potential hazard to prenatal chromosomal diagnosis

E L Schneider et al. Science. .

Abstract

Amniotic fluid cell cultures were screened for mycoplasma contamination. Mycoplasma RNA's were observed in more than half the cultures examined. Karyotypic analyses of these contaminated cell cultures revealed a significant increase in chromosomal aberrations. These studies emphasize the need for screening for mycoplasma in cultured amniotic cells.

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