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. 1974 Feb;138(2):233-7.
doi: 10.1042/bj1380233.

Sterol biosynthesis in the free-living nematode Panagrellus redivivus

J D Willett, W L Downey

Sterol biosynthesis in the free-living nematode Panagrellus redivivus

J D Willett et al. Biochem J. 1974 Feb.

Abstract

The fate of the known sterol precursor squalene 2,3-oxide was investigated in the free-living nematode Panagrellus redivivus. The nematodes were cultured axenically in the presence of [4-(3)H]squalene 2,3-oxide. Radioactivity was found in the total lipids of the isolated nematodes. Essentially all of the radioactivity encountered in the total lipids was found in the non-saponifiable fraction. The components present in the non-saponifiable fraction were separated and isolated by t.l.c. Three labelled components were identified by a combination of t.l.c., g.l.c. and mass spectroscopy. It is established that P. redivivus has the capacity for biosynthesis of lanosterol. No labelled C(27) sterols could be detected.

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References

    1. Science. 1968 May 17;160(3829):778-80 - PubMed
    1. Science. 1970 Apr 3;168(3927):143-4 - PubMed
    1. Steroids. 1970 Aug;16(2):141-71 - PubMed
    1. Comp Biochem Physiol. 1968 Oct;27(1):309-17 - PubMed
    1. Lipids. 1971 Apr;6(4):219-24 - PubMed