Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1974 Feb;138(2):277-80.
doi: 10.1042/bj1380277.

Synthesis of radioactive dolichol from (4S-3H)mevalonate in the regenerating rat liver

H G Martin, K J Thorne
Comparative Study

Synthesis of radioactive dolichol from (4S-3H)mevalonate in the regenerating rat liver

H G Martin et al. Biochem J. 1974 Feb.

Abstract

The dolichol of rat liver was labelled by injecting [4S-(3)H]mevalonate, the precursor of cis-isoprene residues, into partially hepatectomized animals. The optimum conditions for labelling the dolichol were to inject the animals with radioactive mevalonate 48h after hepatectomy and to kill them 12h later. The concentration of radioactive dolichol was five times as great in regenerating rat liver as in normal liver. The highest concentration of radioactive dolichol was found in the crude mitochondrial and nuclear-debris fractions of the cell. The crude microsomal fractions also contained radioactive dolichol, but at a lower concentration.

PubMed Disclaimer

References

    1. Proc R Soc Lond B Biol Sci. 1966 Jan 18;163(993):492-514 - PubMed
    1. Arch Biochem Biophys. 1966 Mar;113(3):646-53 - PubMed
    1. Biochem J. 1966 Apr;99(1):123-7 - PubMed
    1. Arch Biochem Biophys. 1968 Nov;128(2):503-8 - PubMed
    1. Anal Biochem. 1969 Jun;29(3):351-6 - PubMed

Publication types