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Comparative Study
. 1974 Feb;138(2):313-6.
doi: 10.1042/bj1380313.

Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate

A P Halestrap, R M Denton
Comparative Study

Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate

A P Halestrap et al. Biochem J. 1974 Feb.

Abstract

alpha-Cyano-4-hydroxycinnamate greatly inhibits the transport of pyruvate but not that of acetate or butyrate in liver mitochondria and erythrocytes. In the latter, lactate uptake is also inhibited. It is concluded that a specific carrier is involved in membrane transport of pyruvate and that the plasma-membrane carrier may also be involved in lactate transport.

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References

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    1. Biochim Biophys Acta. 1970 Aug 4;216(1):63-70 - PubMed
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