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. 1974 Apr 20;2(5911):140-2.
doi: 10.1136/bmj.2.5911.140.

Some metabolic effects of sodium nitroprusside in man

C J Vesey, P V Cole, J C Linnell, J Wilson

Some metabolic effects of sodium nitroprusside in man

C J Vesey et al. Br Med J. .

Abstract

The infusion of sodium nitroprusside during surgical operations produced plasma levels of cyanide of up to four times the control value. Plasma thiocyanate showed little change except during prolonged infusion of the drug, but total plasma B(12) tended to fall, as did methylcobalamin. Other cobalamins showed little change after nitroprusside infusion for short periods. During longer infusions the ratio of methylcobalamin to adenosyl + hydroxocobalamin fell and cyanocobalamin concentrations were high.

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References

    1. Clin Sci. 1966 Aug;31(1):1-7 - PubMed
    1. J Pharmacol Exp Ther. 1968 Aug;162(2):352-9 - PubMed
    1. Br J Anaesth. 1968 Oct;40(10):804-5 - PubMed
    1. J Clin Pathol. 1967 Sep;20(5):683-6 - PubMed
    1. J Clin Pathol. 1969 Sep;22(5):545-50 - PubMed

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