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. 1974 May;53(5):1468-72.
doi: 10.1172/JCI107695.

Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction

J B Smith, C Ingerman, J J Kocsis, M J Silver

Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction

J B Smith et al. J Clin Invest. 1974 May.

Abstract

A compound that could be converted to prostaglandin F(2alpha) by mild chemical reduction was formed by human platelets in response to arachidonic acid, collagen, or L-epinephrine. It was present in maximal amounts at about 1 min after addition of arachidonic acid or collagen to platelet-rich plasma. Its initial formation appeared to precede platelet aggregation by these agents and was closely correlated with the release of adenine nucleotides and radioactive 5-hydroxytryptamine from platelets. Moreover, the compound was itself found outside the platelets. This compound is probably an endoperoxide intermediate in prostaglandin biosynthesis and may be a trigger for the platelet release reaction.

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