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. 1975 Apr;72(4):1268-71.
doi: 10.1073/pnas.72.4.1268.

Evolution of biosynthetic pathways: immunological approach

P Truffa-Bachi, N Guiso, G N Cohen, J Theze, B Burr

Evolution of biosynthetic pathways: immunological approach

P Truffa-Bachi et al. Proc Natl Acad Sci U S A. 1975 Apr.

Abstract

Through the use of specific immunoadsorbent columns, it is shown that Escherichia coli aspartokinase I-homoserine dehydrogenase I, aspartokinase II-homoserine dehydrogenase II, aspartokinase III, and homoserine kinase, enzymes involved in the same complex biosynthetic pathway, share antigenic determinants. This raises the question of a common origin for the four cibtenoirart kinases. (Aspartate kinase or ATP:L aspartate 4-phosphotransferase, EC 2.7.2.4; homoserine dehydrogenase or Lhomoserine:NADP oxidoreductase, EC 1.1.1.3; homoserine kinase or ATP:L-homoserine O-phosphotransferase, EC 2.7.1.39.)

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