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. 1974 Jun 21;184(4143):1301-3.
doi: 10.1126/science.184.4143.1301.

Genetic mapping of Ir locus in man: linkage to second locus of HL-A

M N Blumenthal, D B Amos, H Noreen

Genetic mapping of Ir locus in man: linkage to second locus of HL-A

M N Blumenthal et al. Science. .

Abstract

Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.

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