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Clinical Trial
. 1974 Jun 15;2(5919):589-91.
doi: 10.1136/bmj.2.5919.589.

Degree and duration of reversal by naloxone of effects of morphine in conscious subjects

J M Evans, M I Hogg, J N Lunn, M Rosen
Clinical Trial

Degree and duration of reversal by naloxone of effects of morphine in conscious subjects

J M Evans et al. Br Med J. .

Abstract

The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.

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