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. 1974 Jun 22;2(5920):656-9.
doi: 10.1136/bmj.2.5920.656.

Controlled sedation with alphaxalone-alphadolone

M A Ramsay, T M Savege, B R Simpson, R Goodwin

Controlled sedation with alphaxalone-alphadolone

M A Ramsay et al. Br Med J. .

Abstract

Alphaxalone-alphadolone (Althesin), diluted and administered as a controlled infusion, was used as a sedative for 30 patients in an intensive therapy unit. This technique allowed rapid and accurate control of the level of sedation. It had three particularly useful applications: it provided "light sleep," allowed rapid variation in the level of sedation, and enabled repeated assessment of the central nervous system.Sedation was satisfactory for 86% of the total time, and no serious complications were attributed to the use of the drug. Furthermore, though alphaxalone-alphadolone was given for periods up to 20 days there was no evidence of tachyphylaxis or delay in recovery time.

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References

    1. Br J Anaesth. 1972 Jun;44(6):590-2 - PubMed
    1. Br J Anaesth. 1972 Aug;44(8):751-7 - PubMed
    1. Br J Anaesth. 1973 Feb;45(2):168-72 - PubMed
    1. Br J Anaesth. 1973 May;45(5):481-5 - PubMed

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