doi: 10.1126/science.185.4153.789.
Complement-dependent stimulation of prostaglandin synthesis and bone resorption
- PMID: 4843377
- DOI: 10.1126/science.185.4153.789
Item in Clipboard
Complement-dependent stimulation of prostaglandin synthesis and bone resorption
Science.
.
Abstract
Complement-sufficient heterologous serum induced prostaglandin synthesis and resultant resorption in cultures of fetal rat long bones. Bone resorption was enhanced with unheated normal rabbit serum as compared to heated serum or serum from rabbits lacking the sixth component of complement (C6). Addition of functionally purified C6 restored resorptive activity in C6-deficient serum. Concentrations of prostaglandin E were increased in the culture media of bones incubated with complement-sufficient serum. The resorptive effects of active serum as well as the appearance of prostaglandin E in the media were inhibited by indomethacin.
Similar articles
-
Enhancement of complement-mediated prostaglandin synthesis and bone resorption by arachidonic acid and inhibition by cortisol.Prostaglandins Leukot Med. 1982 May;8(5):419-27. Prostaglandins Leukot Med. 1982. PMID: 6808524
-
Effects of DNA and prostaglandin synthesis inhibitors on the stimulation of bone resorption by epidermal growth factor in fetal rat long-bone cultures.J Clin Invest. 1986 Jun;77(6):1897-902. doi: 10.1172/JCI112517. J Clin Invest. 1986. PMID: 3086384 Free PMC article.
-
Phorbol esters stimulate bone resorption in fetal rat long-bone cultures by mechanisms independent of prostaglandin synthesis.J Bone Miner Res. 1988 Feb;3(1):63-7. doi: 10.1002/jbmr.5650030110. J Bone Miner Res. 1988. PMID: 3145672
-
Prostaglandin synthesis by fetal rat bone in vitro: evidence for a role of prostacyclin.Prostaglandins. 1979 Jun;17(6):905-14. doi: 10.1016/0090-6980(79)90061-3. Prostaglandins. 1979. PMID: 388530
-
Prostaglandin in calcium and bone metabolism.Clin Orthop Relat Res. 1975 Sep;(111):228-37. doi: 10.1097/00003086-197509000-00030. Clin Orthop Relat Res. 1975. PMID: 1098825 Review.
Cited by
-
Direct stimulation of bone resorption by thyroid hormones.J Clin Invest. 1976 Sep;58(3):529-34. doi: 10.1172/JCI108497. J Clin Invest. 1976. PMID: 182721 Free PMC article.
-
N-acetyl muramyl dipeptide stimulation of bone resorption in tissue culture.Infect Immun. 1982 Jan;35(1):133-7. doi: 10.1128/iai.35.1.133-137.1982. Infect Immun. 1982. PMID: 7054120 Free PMC article.
-
Some mechanisms of local bone destruction by squamous carcinomas of the head and neck.Br J Cancer. 1981 Mar;43(3):392-401. doi: 10.1038/bjc.1981.60. Br J Cancer. 1981. PMID: 7225288 Free PMC article.
-
High turnover osteoporosis in acro-osteolysis (Hajdu-Cheney syndrome).J Endocrinol Invest. 1990 Mar;13(3):251-5. doi: 10.1007/BF03349553. J Endocrinol Invest. 1990. PMID: 2365959
-
Direct measurement of the increase in intracellular free calcium ion concentration in response to the action of complement.Biochem J. 1981 Feb 15;194(2):551-60. doi: 10.1042/bj1940551. Biochem J. 1981. PMID: 6272733 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
