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. 1974 Mar;50(3):431-4.
doi: 10.1111/j.1476-5381.1974.tb09621.x.

Enhancement of pentagastrin-induced gastric acid secretion by clonidine in the conscious dog

B P Curwain, K Endersby

Enhancement of pentagastrin-induced gastric acid secretion by clonidine in the conscious dog

B P Curwain et al. Br J Pharmacol. 1974 Mar.

Abstract

The effect of intravenous clonidine on pentagastrin-induced gastric acid secretion has been studied in conscious dogs with Heidenhain pouches. Dose-dependent enhancement of secretion was found in response to clonidine (5-20 mu/kg). Clonidine (20 mug/kg) increased the maximal secretory rate to pentagastrin to a value not significantly different from the maximal response to histamine.

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