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. 1974 Jun;139(3):699-708.
doi: 10.1042/bj1390699.

Studies on the heparin sulphamidase activity from rat spleen. Intracellular distribution and characterization of the enzyme

Y Friedman, C Arsenis

Studies on the heparin sulphamidase activity from rat spleen. Intracellular distribution and characterization of the enzyme

Y Friedman et al. Biochem J. 1974 Jun.

Abstract

A sulphamidase activity present in rat spleen capable of hydrolysing N-[(35)S]sulphated heparin was studied. This activity was associated with the lysosomal fraction. Studies in vivo showed that the rat is capable of significantly desulphating heparin. Lysosomes in all the major tissues can effectively accumulate heparin. The heparin sulphamidase and arylsulphatase activities from rat spleen were separated by isoelectric focusing. Heparin sulphamidase was a distinct entity from all the arylsulphatase activities.

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References

    1. Biochem J. 1960 Mar;74:450-6 - PubMed
    1. J Biol Chem. 1970 Aug 25;245(16):4001-8 - PubMed
    1. J Biol Chem. 1961 May;236:1372-9 - PubMed
    1. J Biol Chem. 1951 Apr;189(2):665-70 - PubMed
    1. Biochem J. 1959 Dec;73:623-8 - PubMed