Work-induced hypertrophy in exercised normal muscles of different ages and the reversibility of hypertrophy after cessation of exercise

Abstract

1. Groups of male hamsters of different ages were subjected to a weight-lifting exercise regimen, and the biceps brachii, soleus and extensor digitorum longus (EDL) muscles examined for structural changes occurring in response to the increased workload. In addition, two groups of adult hamsters were left to recover from the exercise stimulus for 5 and 15 weeks respectively.2. All the exercised muscles exhibited muscle fibre hypertrophy, and the extent of the hypertrophy was greater in the younger animals. In all age groups, the biceps brachii and EDL showed more hypertrophy than did the soleus. There was no significant increase in fibre number after exercise.3. In both groups allowed to recover from the exercise stimulus, the fibre dimensions reverted back to those of the control muscles; this appeared to be complete after 15 weeks recovery.4. Electron microscopical studies of fibres from exercised and control biceps brachii revealed no significant changes with exercise in the proportions present of myofibrillar, mitochondrial and tubular components within muscle fibres of the same size.