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. 1974 Jun;139(3):791-2.
doi: 10.1042/bj1390791.

X-ray evidence for metal-N-7 bonding in a hydrated manganese derivative of guanosine 5'-monophosphate

P De Meester, D M Goodgame, T J Jones, A C Skapski

X-ray evidence for metal-N-7 bonding in a hydrated manganese derivative of guanosine 5'-monophosphate

P De Meester et al. Biochem J. 1974 Jun.

Abstract

Single-crystal X-ray studies of a manganese(II) derivative of guanosine 5'-monophosphate, [Mn(5'-GMP)(H(2)O)(5)],3H(2)O, have shown that it is isostructural with its nickel analogue. The manganese atom therefore is bonded to five water molecules with the remaining octahedral co-ordination site being occupied by N-7 of the nucleotide base. No direct metal-phosphate bonding is involved, but there are structure-stabilizing intramolecular hydrogen bonds between two phosphate oxygen atoms and co-ordinated water molecules.

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