Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Jun;38(3):215-8.
doi: 10.1136/ard.38.3.215.

Directed migration of circulating polymorphonuclear leucocytes in patients with rheumatoid arthritis: a defect in the plasma

J R Walker, D W James, M J Smith

Directed migration of circulating polymorphonuclear leucocytes in patients with rheumatoid arthritis: a defect in the plasma

J R Walker et al. Ann Rheum Dis. 1979 Jun.

Abstract

The migration of peripheral polymorphonuclear leucocytes (PMNs) of patients with rheumatoid arthritis has been studied both in vivo and in vitro. A significant reduction in the accumulation of PMNs in skin chambers in patients with rheumatoid arthritis compared to controls was observed but no defect in cell movement was detected when the isolated PMNs from the patients were exposed to activated control plasma. However, when PMNs from the control group were tested against activated plasma from patients with rheumatoid arthritis there was a significant decrease in their chemotactic response. It is proposed that there is a humoral defect in the plasma of the patients.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lancet. 1977 Aug 20;2(8034):379-81 - PubMed
    1. Clin Exp Immunol. 1977 Jun;28(3):413-25 - PubMed
    1. Am J Pathol. 1977 Sep;88(3):701-10 - PubMed
    1. Am J Pathol. 1977 Sep;88(3):711-26 - PubMed
    1. Ann Rheum Dis. 1976 Dec;35(6):510-5 - PubMed