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. 1979 Jan-Mar;23(1):174-8.

Toxicity of endotoxin to chicks

H E Adler, A J DaMassa
  • PMID: 486001

Toxicity of endotoxin to chicks

H E Adler et al. Avian Dis. 1979 Jan-Mar.

Abstract

Large doses of purified lipopolysaccharide (LPS) purified from Escherichia coli induced clinical signs but no mortality in chicks. Five chicks survived a mean dose of 517 mg/kg. One individual that received LPS at 577 mg/kg recovered from clinical manifestations within two days. Attempts failed to produce a generalized Shwartzman-like reaction with two intravenous inoculations of LPS at about 24-hour intervals. Prior injection of uric acid did not protect chicks from LPS by intravenous exposure.

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