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. 1979 Jun 15;180(3):579-85.
doi: 10.1042/bj1800579.

A potassium ion diffusion potential causes adrenaline uptake in chromaffin-granule 'ghosts'

D Njus, G K Radda

A potassium ion diffusion potential causes adrenaline uptake in chromaffin-granule 'ghosts'

D Njus et al. Biochem J. .

Abstract

Membrane vesicles ('ghosts') formed from bovine chromaffin granules accumulate adrenaline in response to a diffusion potential produced by adding K+ in the presence of valinomycin. This uptake occurs as a short (2--5 min) burst because of the transient nature of the diffusion potential. The potential-driven uptake is optimal at pH approximately 7.2, is inhibited by reserpine, and has an initial rate comparable with that of ATP-driven uptake. These results show that ATP-dependent adrenaline uptake may occur at least partly in response to the membrane potential generated by an electrogenic proton-translocating adenosine triphosphatase found in chromaffin-granule membranes.

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