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. 1979 Jul 1;181(1):241-43.
doi: 10.1042/bj1810241.

On the molecular-weight-dependence of the anticoagulant activity of heparin

L Thunberg, U Lindahl, A Tengblad, T C Laurent, C M Jackson

On the molecular-weight-dependence of the anticoagulant activity of heparin

L Thunberg et al. Biochem J. .

Abstract

The inactivation of thrombin and factor Xa by antithrombin was determined in the presence of heparin fractions of different molecular weights and with high affinity for antithrombin. The ability to potentiate the inactivation of either coagulation factor increased with increasing length of the polysaccharide chain.

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References

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    1. Biochem J. 1978 Nov 1;175(2):691-701 - PubMed
    1. Thromb Res. 1976 Dec;9(6):575-83 - PubMed
    1. FEBS Lett. 1976 Oct 15;69(1):51-4 - PubMed

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