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. 1979 Jul 1;181(1):247-50.
doi: 10.1042/bj1810247.

Inhibition of human alkaline phosphatases by vanadate

L E Seargeant, R A Stinson

Inhibition of human alkaline phosphatases by vanadate

L E Seargeant et al. Biochem J. .

Abstract

Orthovanadate was shown to be a potent competitive inhibitor (Ki less than 1 microM) of purified alkaline phosphatase from human liver, intestine of kidney. Inhibition was reversed and full enzymic activity restored in the presence of 1mM-adrenaline. Phosphate and vanadate competed for the same binding site on the enzyme.

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