Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1967 Nov;94(5):1609-15.
doi: 10.1128/jb.94.5.1609-1615.1967.

Unusual growth characteristics of a methionine-cyano-B12 auxotroph of Escherichia coli

H Dickerman, R T Taylor, H Weissbach

Unusual growth characteristics of a methionine-cyano-B12 auxotroph of Escherichia coli

H Dickerman et al. J Bacteriol. 1967 Nov.

Abstract

Escherichia coli K-12, strain AB1172, substrain 2276, a methionine(-)-cyano-B(12) (-) auxotroph grew poorly when placed in a medium containing optimal levels of cyano-B(12) and suboptimal amounts of l-methionine. A marked depression of N(5,10)-methylene-H(4)-folate reductase was observed in the inhibited cells, although no significant alterations in other enzymes involved in the metabolism of N(5,10)-methylene-H(4)-folate were observed. Guanosine was effective in preventing the growth inhibition.

PubMed Disclaimer

References

    1. Biochem Biophys Res Commun. 1966 Feb 3;22(3):340-5 - PubMed
    1. Biochem Biophys Res Commun. 1964 Aug 11;16(6):593-9 - PubMed
    1. Arch Biochem Biophys. 1966 Nov;117(2):405-12 - PubMed
    1. Biochim Biophys Acta. 1951 Nov;7(4):585-99 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed

LinkOut - more resources