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. 1968 Apr;63(4):658-68.

Studies of blood flow and ultrastructural changes in rejecting and nonrejecting canine orthotopic liver homografts

C G Groth, K A Porter, J B Otte, P M Daloze, T L Marchioro, L Brettschneider, T E Starzl

Studies of blood flow and ultrastructural changes in rejecting and nonrejecting canine orthotopic liver homografts

C G Groth et al. Surgery. 1968 Apr.
No abstract available

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Figures

Fig. 1
Fig. 1
The placement of indwelling catheters in the portal and hepatic arterial systems in the donor (A) and the recipient animal (B). Note that the gastroduodenal artery in the donor is tied to ensure delivery of the isotope solely to the liver.
Fig. 2
Fig. 2
Semilogarithmic plots of typical disappearance curves following injection of Xe133. Usually most of the plot was a straight line (A). In some instances, however, it was a curve that could be resolved into 2 compartments (B).
Fig. 3
Fig. 3
Liver blood flow as measured by portal injection (FPI) and hepatic arterial injection (FAI) in the donor and recipient on the days before and after transplantation. Cardiac output and liver function are also shown. Mean values ± SE in 9 experiments are depicted.
Fig. 4
Fig. 4
Liver blood flow, cardiac output, and liver function in 7 unmodified recipients that died of rejection. The mean values ± SE are shown, as well as the number of observations (in parentheses) for each day.
Fig. 5
Fig. 5
Liver blood flow, cardiac output, and liver function in a recipient receiving immunosuppression. The animal died of rejection 13 days after transplant. Note the concomitant improvement of flow and liver function on Day 11, indicating reversibility of the flow changes.
Fig. 6
Fig. 6
Liver blood flow, cardiac output, and liver function in 4 recipients which received immunosuppression and had little or no evidence of rejection. Mean values ± SE are given, as well as the numbers of observation (in parentheses).
Fig. 7
Fig. 7
Biopsy, 4 days after transplantation, of an hepatic homograft in an untreated dog. Electron micrograph showing a central hepatic vein. Lymphocytes (ly), platelets (p), and fibrin (f) lie beneath the endothelial lining (end) of the vessel. Fluid and cells lie in the perivascular space (per = pericyte; m = macrophage; lu = lumen of vein). (Lead stain. ×2,250.)
Fig. 8
Fig. 8
Biopsy of canine hepatic homograft, 4 days after transplantation. Electron micrograph showing a centrilobular sinusoid. The endothelial lining (end) is ruptured at the point marked with arrow. The space of Disse is wider than normal and contains a red cell (rbc) and fluid (fl). A lymphoid cell (ly) and two erythrocytes (rbc) are present in the lumen (lu) of the sinusoid. The adjacent hepatocytes (hep) are injured, as shown by swelling and clumping of their mitochondria and loss of their rough endoplasmic reticulum. (Lead stain. ×6,000.)
Fig. 9
Fig. 9
Biopsy of untreated canine hepatic homograft, 4 days after transplantation. Electron micrograph showing part of wall of a vein in a small portal tract. The wall is infiltrated by lymphocytes (ly), macrophages (m), and fibrin (f) (lu = lumen of vein; end = endothelial lining cells.) (Lead stain, ×6,000.)
See this image and copyright information in PMC

References

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