Genetic map position of the gluconate-6-phosphate dehydrogenase gene in Salmonella typhimurium
- PMID: 4869214
- PMCID: PMC315083
- DOI: 10.1128/jb.95.4.1279-1282.1968
Genetic map position of the gluconate-6-phosphate dehydrogenase gene in Salmonella typhimurium
Abstract
Gluconate-6-phosphate dehydrogenase (GND) is genetically determined in Salmonella typhimurium by a locus (gnd) mapping between the somatic antigen (rfb) and histidine (his) operons. The enzyme is constitutive. Strains of Salmonella carrying an F' genetic element which contains the gnd(+) gene have GND activity two to three times that of the wild type. This gene dosage effect was used to determine that the GND reaction is not rate-limiting for the metabolism of glucose by the pentose shunt in S. typhimurium.
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