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. 1968 May;95(5):1666-71.
doi: 10.1128/jb.95.5.1666-1671.1968.

Isoleucine and valine metabolism of Escherichia coli. XIV. Effect of thiaisoleucine

A Szentirmai, H E Umbarger

Isoleucine and valine metabolism of Escherichia coli. XIV. Effect of thiaisoleucine

A Szentirmai et al. J Bacteriol. 1968 May.

Abstract

Thiaisoleucine (2-amino-3-methylthiobutyrate) completely inhibited the growth of strain K-12 of Escherichia coli at a concentration of 5 x 10(-3)m. The inhibition was antagonized by growth-factor amounts of l-isoleucine. Thiaisoleucine inhibited the deamination of threonine and the transfer of (14)C-isoleucine to soluble ribonucleic acid and underwent transamination with alpha-ketoglutarate as the amino acceptor. In each case, the analogue appeared to be less effective than isoleucine as either an inhibitor or substrate.

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References

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    1. J Biol Chem. 1961 Jan;236:200-2 - PubMed
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