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. 1979 Sep;26(5):353-60.
doi: 10.1007/BF03006447.

Ventilation and chemoreflexes during enflurane sedation and anaesthesia in man

R L Knill, P H Manninen, J L Clement

Ventilation and chemoreflexes during enflurane sedation and anaesthesia in man

R L Knill et al. Can Anaesth Soc J. 1979 Sep.

Abstract

Enflurane sedation and anaesthesia in healthy fit subjects reduced ventilation and the response to carbon dioxide, hypoxaemia and a low dose of doxapram, all in a dose-related fashion. Comparing the three chemoreflexes tested, the response to hypoxaemia and doxapram were the more profoundly impaired; they were nearly totally abolished by anaesthesia. These effects of enflurane on chemoreflex activities are qualitatively similar to those previously observed with halothane.

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