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. 1979 Sep;26(5):381-5.
doi: 10.1007/BF03006452.

Epidural analgesia and the metabolic response to surgery

G M Cooper, A Holdcroft, G M Hall, J Alaghband-Zadeh

Epidural analgesia and the metabolic response to surgery

G M Cooper et al. Can Anaesth Soc J. 1979 Sep.

Abstract

The effect of epidural blockade on the metabolic and hormonal responses to pelvic surgery was investigated in 14 female patients. Central venous blood samples were collected every 30 minutes and analysed for free fatty acids, glycerol, beta-hydroxybutyrate, acetoacetate, glucose, lactate, pyruvate, cortisol and growth hormone concentrations. There was no change in fat and glucose metabolism except for a transient decrease in lipolysis after 30 minutes of surgery. Cortisol and growth hormone values were significantly increased (p less than 0.01) after 60 minutes. A small but statistically significant increase in blood lactate concentration was observed (p less than 0.01) and the concept of a "metabolic V/Q" abnormality is postulated to explain the lacticacidaemia.

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