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. 1968 Aug 16;161(3842):706-8.
doi: 10.1126/science.161.3842.706.

Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe

G K Aghajanian, W E Foote, M H Sheard

Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe

G K Aghajanian et al. Science. .

Abstract

Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased metabolism of serotonin produced by this drug.

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