doi: 10.2165/00003088-197904040-00004.
Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man
- PMID: 487686
- DOI: 10.2165/00003088-197904040-00004
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Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man
Clin Pharmacokinet.
1979 Jul-Aug.
Abstract
The pharmacokinetics of N1-acetylsulphamethoxazole and N4-acetylsulphamethoxazole in man are described. N1-Acetylsulphamethoxazole is deacetylated to sulphamethoxazole and acetylated to N4-acetylsulphamethoxazole. N4-Acetylsulphamethoxazole is excreted almost unchanged in the urine. The renal excretion rate is independent of the urine flow and urinary pH. N4-Acetylsulphonamides are less lipid soluble and more acidic than their corresponding parent sulphonamides.
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